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KMID : 0376219750120010243
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Chonnam Medical Journal
1975 Volume.12 No. 1 p.243 ~ p.251
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Additive Effect of Belladonna Alkaloids and Neostigmine or Methacholine
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Abstract
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1. Atropine (0.2 mg), scopolamine (0. 1 mg) and neostigmine(0.5 mg) produced bradycardia in human volunteers.
2. Neostigmine further decreased the pulse rate which had been decreased by acropine or scopolamine.
3. Atropine or scopolaniine´further decreased the pulse rate which had been decreased by neostigmine.
4. In rabbits, atropine (10-250 ? g/kg) and methacholine produced hypotensive responses. The hypotension by atropine was gradual and sustained; that I,by methacholine was sharp and transient.
5. In rabbits methacholine or atropine elicited further hypotensive responses, when given after atropine or methacholine respectively.
6. The discussion was made concerning the mechanism of bradycardia by atropine and scopolamine, and it is concluded that the bradycardia has nothing to do with vagal tone and the muscarinic receptors of the sinoatrial node.
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